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ROBO2 Antibody
SPA-09684
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ROBO2 |
| Gene Abbr. | ROBO2 |
| Gene ID | 6092 |
| Full Name | roundabout guidance receptor 2 |
| Alias | SAX3 |
| Introduction | ROBO2 is a member of the roundabout (ROBO) receptor family. The activation of ROBO2 by SLIT ligand regulates various biological processes, including promoting stem cell senescence via WNT inhibition, destabilizing podocyte actin polymerization and adhesion, and activation of Ena/VASP to facilitate tumor cell extrusion from epithelia. In development, the SLIT-ROBO pathways play important roles in neuronal axon guidance and synapse function, retinal neurovascular formation, and muscle patterning. Loss of function mutations of ROBO2 have been associated with urinary tract anomalies and vesicoureteral reflux. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | E4M6D |
| Immunogen | Synthetic peptide corresponding to residues surrounding Leu1172 of human ROBO2 protein. |
| Source/Purification | Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1172 of human ROBO2 protein. |
| Usage | |
|---|---|
| Application | WB, IP, IF |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 180, 220 |
| Reactivity | Human, Mouse, Rat |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total ROBO2 protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.