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RGS4 Antibody
SPA-09587
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | RGS4 |
| Gene Abbr. | RGS4 |
| Gene ID | 5999 |
| Full Name | regulator of G protein signaling 4 |
| Alias | RGP4, SCZD9 |
| Introduction | Regulators of G protein signaling (RGS) are a family of about 40 proteins that determine the signaling amplitude and duration of G protein-coupled receptor signaling via modulation of the GTPase activity of G proteins. Each RGS has a distinct structure, expression pattern, and regulation, resulting in preferential interactions with receptors, G proteins, and other signaling proteins, as well as a unique function.Regulator of G-protein signaling 4 (RGS4) is a small RGS (23 kDa) that belongs to the R4 subfamily of heterotrimeric G-protein regulators. RGS4 contains a short amino-terminus that may be responsible for its functional specificity towards G-protein-coupled receptors, and a conserved RGS domain responsible for GAP activity. The RGS4 protein shares activity at both Gαq and Gαi/o proteins. Degradation of RGS4 is regulated by opioid receptor-mediated ubiquitination following stimulation by opioid receptor agonists, such as the DAMGO synthetic opioid peptide. RGS4 modulates the action of morphine and other opiates in vivo. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D4V1P |
| Immunogen | Recombinant protein specific to the amino terminus of human RGS4 protein. |
| Source/Purification | Antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human RGS4 protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 25 |
| Reactivity | Human, Mouse, Rat |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total RGS4 protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.