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Recombinant Rat Spectrin alpha chain, brain (Sptan1), partial
SPP-05471
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Rattus norvegicus |
| Target Name | α-Fodrin |
| UniProt No. | P16086 |
| Subcellular Location | Cytoplasm, cytoskeleton, Cytoplasm, cell cortex |
| Tissue Specificity | Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). |
| Gene Abbr. | Sptan1 |
| Full Name | spectrin, alpha, non-erythrocytic 1 |
| Alias | A2a, IPF, Spna2 |
| Introduction | Fodrin (also named nonerythroid spectrin) is a universally expressed membrane-associated cytoskeletal protein consisting of alpha- and beta-subunits. This protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha-fodrin is one of the primary targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases to yield amino-terminal 150 kDa, carboxy-terminal 120 kDa and 35 kDa major products. Cleavage of alpha-fodrin leads to membrane malfunction and cell shrinkage. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.