Recombinant Rat Neurogenic locus notch homolog protein 2 (Notch2), partial - CD BioSciences

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Recombinant Rat Neurogenic locus notch homolog protein 2 (Notch2), partial

Recombinant Rat Neurogenic locus notch homolog protein 2 (Notch2), partial

SPP-03896

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500 μg Online Inquiry
Target Information
Species Rattus norvegicus
Target Name Notch2
UniProt No. Q9QW30
Subcellular Location Notch 2 extracellular truncation: Cell membrane, Single-pass type I membrane protein; Notch 2 intracellular domain: Nucleus, Cytoplasm
Tissue Specificity Highly expressed in the spleen and choroid plexus in the brain. Expressed in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS.
Gene Abbr. NOTCH2
Full Name notch receptor 2
Introduction Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (By similarity).
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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