Recombinant Rat Mitogen-activated protein kinase kinase kinase 8 (Map3k8) - CD BioSciences

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Recombinant Rat Mitogen-activated protein kinase kinase kinase 8 (Map3k8)

Recombinant Rat Mitogen-activated protein kinase kinase kinase 8 (Map3k8)

SPP-05191

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500 μg Online Inquiry
Target Information
Species Rattus norvegicus
Target Name Tpl2
UniProt No. Q63562
Subcellular Location Cytoplasm
Tissue Specificity Expressed in spleen, thymus, liver and lung.
Gene Abbr. Map3k8
Full Name mitogen-activated protein kinase kinase kinase 8
Alias D17TPL2, Tpl-2, Tpl2
Introduction Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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