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Recombinant Rat Disks large homolog 4 (Dlg4)
SPP-04477
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Rattus norvegicus |
| Target Name | PSD95 |
| UniProt No. | P31016 |
| Subcellular Location | Cell membrane, Lipid-anchor, Cytoplasmic side, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cell junction, synapse, Cytoplasm, Cell projection, axon |
| Tissue Specificity | Expressed in brain (at protein level) (PubMed:12151521, PubMed:27307232). Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (PubMed:20089912). |
| Gene Abbr. | Dlg4 |
| Full Name | discs large MAGUK scaffold protein 4 |
| Alias | Dlgh4, PSD95, Sap90 |
| Introduction | Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.