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Recombinant Rat C-Jun-amino-terminal kinase-interacting protein 1 (Mapk8ip1)
SPP-03402
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Rattus norvegicus |
| Target Name | JIP1 |
| UniProt No. | Q9R237 |
| Subcellular Location | Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Endoplasmic reticulum membrane, Mitochondrion membrane |
| Tissue Specificity | Highly expressed in brain and pancreatic beta-cells. Weaker expression found in kidney. |
| Gene Abbr. | Mapk8ip1 |
| Full Name | mitogen-activated protein kinase 8 interacting protein 1 |
| Alias | JIP1, Jip-1, Mapk8ip |
| Introduction | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.