Recombinant Rat Beta-arrestin-2 (Arrb2) - CD BioSciences

service-banner

Recombinant Rat Beta-arrestin-2 (Arrb2)

Recombinant Rat Beta-arrestin-2 (Arrb2)

SPP-05482

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Rattus norvegicus
Target Name β-Arrestin 2
UniProt No. P29067
Subcellular Location Cytoplasm, Nucleus, Cell membrane, Membrane, clathrin-coated pit, Cytoplasmic vesicle
Tissue Specificity Predominantly localized in neuronal tissues and in the spleen.
Gene Abbr. Arrb2
Full Name arrestin, beta 2
Alias BARRES
Introduction Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling. Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs. β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways. β-arrestins are also involved in some receptor tyrosine kinase signaling pathways. Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.