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Recombinant Rat Beta-1, 3-N-acetylglucosaminyltransferase radical fringe (Rfng), partial
SPP-04580
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Rattus norvegicus |
| Target Name | RFNG |
| UniProt No. | Q9R1U9 |
| Subcellular Location | Golgi apparatus membrane, Single-pass type II membrane protein |
| Tissue Specificity | Most abundantly expressed in adult brain. Expressed in most neurons of the brain but not in glial cells. Also detected to a lower extent in adult lung and kidney. |
| Gene Abbr. | Rfng |
| Full Name | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Introduction | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (By similarity). Inhibits Notch signaling in postmitotic neurons of the brain. It may play a role in adult brain and in neurogenesis. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.