Recombinant Pig Tumor necrosis factor (TNF) - CD BioSciences

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Recombinant Pig Tumor necrosis factor (TNF)

Recombinant Pig Tumor necrosis factor (TNF)

SPP-05180

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
Target Information
Species Sus scrofa
Target Name TNF-α
UniProt No. P23563
Subcellular Location Cell membrane, Single-pass type II membrane protein; Tumor necrosis factor, membrane form: Membrane, Single-pass type II membrane protein; Tumor necrosis factor, soluble form: Secreted; C-domain 1: Secreted; C-domain 2: Secreted
Gene Abbr. TNF
Full Name tumor necrosis factor
Introduction TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. Membrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer. Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages. Cellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk1/2, p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell death. TNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.