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Recombinant Mouse Serine/threonine-protein kinase/endoribonuclease IRE1 (Ern1), partial
SPP-03348
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Mus musculus |
| Target Name | IRE1α |
| UniProt No. | Q9EQY0 |
| Subcellular Location | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
| Tissue Specificity | Ubiquitously expressed. High levels in thymus, liver and lung. In the brain, preferentially expressed in cortical, hippocampal and olfactory neurons. |
| Gene Abbr. | Ern1 |
| Full Name | endoplasmic reticulum (ER) to nucleus signalling 1 |
| Alias | 9030414B18Rik, AI225830, C85377, Ir, Ire |
| Introduction | Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.