Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj) - CD BioSciences

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Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj)

Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj)

SPP-04562

Size Price
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100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Mus musculus
Target Name RBPSUH
UniProt No. P31266
Subcellular Location Nucleus, Cytoplasm
Gene Abbr. Rbpj
Full Name recombination signal binding protein for immunoglobulin kappa J region
Alias AI843960, CBF1, Igk, Igkj, Igkjrb
Introduction Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity).
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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