Recombinant Mouse Presenilin-1 (Psen1), partial - CD BioSciences

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Recombinant Mouse Presenilin-1 (Psen1), partial

Recombinant Mouse Presenilin-1 (Psen1), partial

SPP-04376

Size Price
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100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Mus musculus
Target Name Presenilin 1
UniProt No. P49769
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Cytoplasmic granule, Cell membrane, Cytoplasmic vesicle
Tissue Specificity Detected in embryonic brain (PubMed:10421573). Detected in adult skin epidermis (at protein level) (PubMed:11517342).
Gene Abbr. PSEN1
Full Name presenilin 1
Introduction Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.