Recombinant Mouse Neurogenic locus notch homolog protein 2 (Notch2), partial - CD BioSciences

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Recombinant Mouse Neurogenic locus notch homolog protein 2 (Notch2), partial

Recombinant Mouse Neurogenic locus notch homolog protein 2 (Notch2), partial

SPP-03895

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Target Information
Species Mus musculus
Target Name Notch2
UniProt No. O35516
Subcellular Location Notch 2 extracellular truncation: Cell membrane, Single-pass type I membrane protein; Notch 2 intracellular domain: Nucleus, Cytoplasm
Tissue Specificity Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.
Gene Abbr. Notch2
Full Name notch 2
Alias AI853703, N, N2
Introduction Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (By similarity).
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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