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Recombinant Mouse Insulin receptor substrate 2 (Irs2), partial
SPP-03357
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Mus musculus |
| Target Name | IRS-2 |
| UniProt No. | P81122 |
| Subcellular Location | Cytoplasm, cytosol |
| Tissue Specificity | Skeletal muscle, lung, brain, liver, kidney, heart and spleen. |
| Gene Abbr. | Irs2 |
| Full Name | insulin receptor substrate 2 |
| Alias | Ir, Irs-2 |
| Introduction | Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase. In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades. IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.