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Recombinant Mouse Forkhead box protein O3 (Foxo3), partial
SPP-01959
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Mus musculus |
| Target Name | FoxO |
| UniProt No. | Q9WVH4 |
| Subcellular Location | Cytoplasm, cytosol, Nucleus |
| Tissue Specificity | Expressed in white and brown adipose tissues (at protein level) (PubMed:22510882). Expressed in liver, kidney, lung and colon (at protein level) (PubMed:29445193). Expressed in skeletal muscles (at protein level) (PubMed:23283301). |
| Gene Abbr. | Foxo3 |
| Full Name | forkhead box O3 |
| Alias | 1110048B16Rik, 2010203A17Rik, C76856, FKHR, FKHRL1 |
| Introduction | The Forkhead family of transcription factors is involved in tumorigenesis of rhabdomyosarcoma and acute leukemias. Within the family, three members (FoxO1, FoxO4, and FoxO3a) have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt. Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1. Forkhead transcription factors also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity. Forkhead transcription factors can also be inhibited by the deacetylase sirtuin (SirT1). |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.