Online Inquiry
Recombinant Mouse DEP domain-containing protein 5 (Depdc5), partial
SPP-01485
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Mus musculus |
| Target Name | DEPDC5 |
| UniProt No. | P61460 |
| Subcellular Location | Cytoplasm, cytosol, Cytoplasm, perinuclear region, Lysosome membrane |
| Tissue Specificity | Expressed at low levels in all brain regions. Expressed throughout brain development, including in midgestation embryonic head (11.5 dpc), neonatal brain and whole adult brain. Present in neurons and absent in non-neuronal cells, including astrocytes. |
| Gene Abbr. | Depdc5 |
| Full Name | DEP domain containing 5 |
| Alias | AV016528 |
| Introduction | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.