Recombinant Mouse Delta-like protein 3 (Dll3) - CD BioSciences

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Recombinant Mouse Delta-like protein 3 (Dll3)

Recombinant Mouse Delta-like protein 3 (Dll3)

SPP-01520

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
Target Information
Species Mus musculus
Target Name DLL3
UniProt No. O88516
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.
Gene Abbr. Dll3
Full Name delta like canonical Notch ligand 3
Alias pu, pudgy
Introduction Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.Mutations in DLL3 cause Spondylocostal dysostoses (SCD), a diverse group of disorders of axial skeletal malformation.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.