Recombinant Mouse Delta-like protein 1 (Dll1), partial - CD BioSciences

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Recombinant Mouse Delta-like protein 1 (Dll1), partial

Recombinant Mouse Delta-like protein 1 (Dll1), partial

SPP-01516

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Target Information
Species Mus musculus
Target Name DLL1
UniProt No. Q61483
Subcellular Location Apical cell membrane, Single-pass type I membrane protein, Cell junction, adherens junction, Membrane raft
Tissue Specificity In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung. Highly expressed in satellite cells from masseter and tongue than in satellite cells from leg.
Gene Abbr. Dll1
Full Name delta like canonical Notch ligand 1
Alias Delt, Delta1
Introduction Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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