Recombinant Mouse Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe (Lfng), partial - CD BioSciences

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Recombinant Mouse Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe (Lfng), partial

Recombinant Mouse Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe (Lfng), partial

SPP-03594

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Target Information
Species Mus musculus
Target Name Lunatic Fringe
UniProt No. O09010
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Tissue Specificity Detected at 12.5 dpc in all tissues examined with the highest level observed in adult brain and spleen. Detected in the dental epithelium.
Gene Abbr. Lfng
Full Name LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Alias AW061165
Introduction Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.