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Recombinant Mouse Bcl-2-like protein 1 (Bcl2l1)
SPP-00588
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Mus musculus |
| Target Name | Bcl-xL |
| UniProt No. | Q64373 |
| Subcellular Location | Mitochondrion membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Tissue Specificity | Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated. |
| Gene Abbr. | Bcl2l1 |
| Full Name | BCL2-like 1 |
| Alias | Bcl, Bcl(X, Bcl(X)L, Bcl-XL, Bcl2l |
| Introduction | Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions. Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents such as paclitaxel, vinblastine and nocodazole. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.