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Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein (FAS) (Active)
SPP-01734
| Size | Price |
| 1 mg | Online Inquiry |
| 500 μg | Online Inquiry |
| 250 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 20 μg | Online Inquiry |
| 5 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | Fas |
| UniProt No. | P25445 |
| Subcellular Location | Isoform 1: Cell membrane, Single-pass type I membrane protein; Isoform 2: Secreted; Isoform 3: Secreted; Isoform 4: Secreted; Isoform 5: Secreted; Isoform 6: Secreted |
| Tissue Specificity | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. |
| Gene Abbr. | FAS |
| Full Name | Fas cell surface death receptor |
| Alias | ALPS1A, APO-1, APT1, CD95, FAS1 |
| Introduction | Association of the receptor Fas with its ligand FasL triggers an apoptotic pathway that plays an important role in immune regulation, development, and progression of cancers. Loss of function mutation in either Fas (lpr mice) or FasL (gld mice) leads to lymphadenopathy and splenomegaly as a result of decreased apoptosis in CD4-CD8- T lymphocytes. FasL (CD95L, Apo-1L) is a type II transmembrane protein of 280 amino acids (runs at approximately 40 kDa upon glycosylation) that belongs to the TNF family, which also includes TNF-α, TRAIL, and TWEAK. Binding of FasL to its receptor triggers the formation of a death-inducing signaling complex (DISC) involving the recruitment of the adaptor protein FADD and caspase-8. Activation of caspase-8 from this complex initiates a caspase cascade resulting in the activation of caspase-3 and subsequent cleavage of proteins leading to apoptosis. Unlike Fas, which is constitutively expressed by various cell types, FasL is predominantly expressed on activated T lymphocytes, NK cells, and at immune privileged sites. FasL is also expressed in several tumor types as a mechanism to evade immune surveillance. Similar to other members of the TNF family, FasL can be cleaved by metalloproteinases producing a 26 kDa trimeric soluble form. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Product Form | Lyophilized powder |
| Buffer before Lyophilization | Lyophilized from a 0.2 µm filtered PBS, pH 7.4. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.