Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active) - CD BioSciences

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Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active)

SPP-05111

Size Price
1 mg Online Inquiry
500 μg Online Inquiry
50 μg Online Inquiry
10 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name TNF receptor
UniProt No. O14798
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Tissue Specificity Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Gene Abbr. TNFRSF10C
Full Name TNF receptor superfamily member 10c
Alias CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3
Introduction The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL). They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain. The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.DR4 (TRAIL-RI, TNFRSF10A) and DR5 (TRAIL-R2, TNFRSF10B) are receptors for the cytokine TRAIL. Both receptors contain death domains that recruit DISC complexes triggering caspase activation and apoptosis. The ability of TRAIL to selectively kill malignant cells has led to clinical studies involving TRAIL and receptor agonists.
Product Details
Product Type Recombinant Protein
Product Form Lyophilized powder
Buffer before Lyophilization Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4.
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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