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Recombinant Human Tumor Necrosis Factor-alpha/TNFSF2 (TNF), partial (Active) (GMP)
SPP-05158
| Size | Price |
| 1 mg | Online Inquiry |
| 100 μg | Online Inquiry |
| 5 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | TNF-α |
| UniProt No. | P01375 |
| Subcellular Location | Cell membrane, Single-pass type II membrane protein; Tumor necrosis factor, membrane form: Membrane, Single-pass type II membrane protein; Tumor necrosis factor, soluble form: Secreted; C-domain 1: Secreted; C-domain 2: Secreted |
| Gene Abbr. | TNF |
| Full Name | tumor necrosis factor |
| Alias | DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F |
| Introduction | TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. Membrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer. Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages. Cellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk1/2, p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell death. TNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Product Form | Lyophilized powder |
| Buffer before Lyophilization | Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM PB, 10 mM NaCl, pH 7.0. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.