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Recombinant Human Suppressor of cytokine signaling 7 (SOCS7)
SPP-04913
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | SOCS7 |
| UniProt No. | O14512 |
| Subcellular Location | Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Nucleus |
| Tissue Specificity | Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. |
| Gene Abbr. | SOCS7 |
| Full Name | suppressor of cytokine signaling 7 |
| Alias | NAP4, NCKAP4 |
| Introduction | Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.