Recombinant Human Protein jagged-1 (JAG1), partial - CD BioSciences

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Recombinant Human Protein jagged-1 (JAG1), partial

Recombinant Human Protein jagged-1 (JAG1), partial

SPP-03380

Size Price
1 mg Online Inquiry
100 μg Online Inquiry
20 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name Jagged1
UniProt No. P78504
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma.
Gene Abbr. JAG1
Full Name jagged canonical Notch ligand 1
Alias AGS, AGS1, AHD, AWS, CD339
Introduction Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.Mutation in Jagged1 is associated with Alagille syndrome, an autosomal dominant disorder characterized by abnormal development of liver, heart, skeleton, eye, and face and Tetralogy of Fallot (ToF), a common form of complex congenital heart disease. Jagged1 expression is associated with prostate cancer metastasis and recurrence.
Product Details
Product Type Recombinant Protein
Buffer before Lyophilization If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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