Recombinant Human Neurogenic locus notch homolog protein 4 (NOTCH4), partial - CD BioSciences

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Recombinant Human Neurogenic locus notch homolog protein 4 (NOTCH4), partial

Recombinant Human Neurogenic locus notch homolog protein 4 (NOTCH4), partial

SPP-03900

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Target Information
Species Homo sapiens
Target Name Notch4
UniProt No. Q99466
Subcellular Location Cell membrane, Single-pass type I membrane protein; Notch 4 intracellular domain: Nucleus
Tissue Specificity Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver.
Gene Abbr. NOTCH4
Full Name notch receptor 4
Alias INT3
Introduction Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes.Notch4 is primarily expressed in endothelial cells and is processed similarly to Notch1. The mouse Notch4 gene (also known as Int-3) is a frequent target in Mouse Mammary Tumour Virus (MMTV)-induced mammary tumors. The intracellular domain of Notch4 binds to Smad3 and inhibits TGF-β signaling.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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