Recombinant Human Neurogenic locus notch homolog protein 2 (NOTCH2), partial - CD BioSciences

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Recombinant Human Neurogenic locus notch homolog protein 2 (NOTCH2), partial

Recombinant Human Neurogenic locus notch homolog protein 2 (NOTCH2), partial

SPP-03894

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name Notch2
UniProt No. Q04721
Subcellular Location Notch 2 extracellular truncation: Cell membrane, Single-pass type I membrane protein; Notch 2 intracellular domain: Nucleus, Cytoplasm
Tissue Specificity Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
Gene Abbr. NOTCH2
Full Name notch receptor 2
Alias AGS2, HJCYS, hN2
Introduction Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.