Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial - CD BioSciences

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Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial

Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial

SPP-03893

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Target Information
Species Homo sapiens
Target Name Notch1
UniProt No. P46531
Subcellular Location Cell membrane, Single-pass type I membrane protein; Notch 1 intracellular domain: Nucleus
Tissue Specificity In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Gene Abbr. NOTCH1
Full Name notch receptor 1
Alias AOS5, AOVD1, TAN1, hN1
Introduction Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes.The NICD of murine Notch1 is released (activated) by cleavage between Gly1743 and Val1744 (corresponding to Gly1753/Val1754 in human Notch1). Mutations that result in constitutive activation of Notch1 are associated with many different cancers, including a majority of cases of T cell acute lymphoblastic leukemia (T-ALL). Activation may be due to mutations in Notch1 itself, or in components of the ubiquitin ligase complex that negatively regulates the Notch signaling pathway.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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