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Recombinant Human Monocyte differentiation antigen CD14 (CD14)
SPP-01004
| Size | Price |
| 500 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 20 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | CD14 |
| UniProt No. | P08571 |
| Subcellular Location | Cell membrane, Lipid-anchor, GPI-anchor, Secreted, Membrane raft, Golgi apparatus |
| Tissue Specificity | Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| Gene Abbr. | CD14 |
| Full Name | CD14 molecule |
| Introduction | CD14 is a leucine-rich repeat-containing pattern recognition receptor with expression largely restricted to the monocyte/macrophage cell lineage. Research studies have shown that CD14 is a bacterial lipopolysaccharide (LPS) binding glycoprotein, expressed as either a GPI-linked membrane protein or a soluble plasma protein. LPS induces an upregulation of GPI-linked CD14 expression, which facilitates TLR4 signaling and macrophage activation in response to bacterial infection. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Buffer before Lyophilization | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Note: If you have any special requirement for the glycerol content, please remark when you place the order. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.