Recombinant Human Mastermind-like protein 1 (MAML1), partial - CD BioSciences

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Recombinant Human Mastermind-like protein 1 (MAML1), partial

Recombinant Human Mastermind-like protein 1 (MAML1), partial

SPP-03596

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name MAML1
UniProt No. Q92585
Subcellular Location Nucleus speckle
Tissue Specificity Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
Gene Abbr. MAML1
Full Name mastermind like transcriptional coactivator 1
Alias Mam-1, Mam1
Introduction Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.