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Recombinant Human DNA damage-inducible transcript 4 protein (DDIT4)
SPP-04570
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | REDD1 |
| UniProt No. | Q9NX09 |
| Subcellular Location | Mitochondrion, Cytoplasm, cytosol |
| Tissue Specificity | Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). |
| Gene Abbr. | DDIT4 |
| Full Name | DNA damage inducible transcript 4 |
| Alias | Dig2, REDD-1, REDD1 |
| Introduction | REDD1 (REgulated in Development and DNA damage responses) expression is induced by hypoxia, cell stress, apoptosis and DNA damage. REDD1 is a transcriptional target of p53 and p63 following DNA damage, and links p63 to Ros. REDD1 functions as a negative regulator of mTOR in response to hypoxia in a tuberin-dependent manner. Depending on cell context, REDD1 can either be protecting or detrimental for cells under oxidative or ischemic stresses. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.