Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), partial - CD BioSciences

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Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), partial

SPP-04986

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name TACE
UniProt No. P78536
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Gene Abbr. ADAM17
Full Name ADAM metallopeptidase domain 17
Alias ADAM18, CD156B, CSVP, NISBD, NISBD1
Introduction TACE (TNF-α converting enzyme), also known as ADAM17, is a transmembrane metalloprotease that plays a key role in the cleavage of a number cell surface molecules in a process known as “shedding". TACE is abundantly expressed in many adult tissues, but in fetal development expression is differentially regulated. An important substrate of TACE is pro-TNF-α. Increased expression of TACE is associated with several pathological conditions including osteoarthritis and rheumatoid arthritis, where the pro-inflammatory effects of increased TNF-α contribute to disease pathogenesis. Regulation of other important molecules by TACE such as EGFR and Notch has recently been documented. TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-α. Some tumors have hyperactivated EGFR due to upregulated TNF-α production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch in a ligand-independent manner and has been shown to play a role in the development of the Drosophila nervous system. TACE has also been proposed to act as α-secretase for amyloid precursor protein (APP) and to be involved in the renewal and proliferation of neural stem cells.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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