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Recombinant Human Delta-like protein 4 (DLL4), partial
SPP-01524
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| 500 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | DLL4 |
| UniProt No. | Q9NR61 |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein |
| Tissue Specificity | Expressed in vascular endothelium. |
| Gene Abbr. | DLL4 |
| Full Name | delta like canonical Notch ligand 4 |
| Alias | AOS6, delta4, hdelta2 |
| Introduction | Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.DLL4 expression is highly restricted to the vascular endothelium and haploinsufficiency of DLL4 results in major defects in vascular systems in mouse. Blockade of DLL4 inhibits tumor growth in model systems. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.