Online Inquiry
Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2), partial, Yeast
SPP-01290
| Size | Price |
| 1 mg | Online Inquiry |
| 500 μg | Online Inquiry |
| 200 μg | Online Inquiry |
| 50 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Homo sapiens |
| Target Name | CREB3L2 |
| UniProt No. | Q70SY1 |
| Subcellular Location | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| Tissue Specificity | Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. |
| Gene Abbr. | CREB3L2 |
| Full Name | cAMP responsive element binding protein 3 like 2 |
| Alias | BBF2H7 |
| Introduction | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Buffer before Lyophilization | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Note: If you have any special requirement for the glycerol content, please remark when you place the order. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.