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Recombinant Cyclic AMP-responsive element-binding protein 3-like protein 2 (creb3l2)
SPP-01287
| Size | Price |
| 20 μg | Online Inquiry |
| 100 μg | Online Inquiry |
| Target Information | |
|---|---|
| Species | Danio rerio |
| Target Name | CREB3L2 |
| UniProt No. | A1L224 |
| Subcellular Location | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| Gene Abbr. | CREB3L2 |
| Full Name | cAMP responsive element binding protein 3 like 2 |
| Introduction | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis. May protect neuroblastoma cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. |
| Product Details | |
|---|---|
| Product Type | Recombinant Protein |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at -20 °C upon receipt unless otherwise instructed. |
| Handling | Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.