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Pref-1/DLK1/FA1 Antibody
SPA-02935
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DLK1 |
| Gene Abbr. | DLK1 |
| Gene ID | 8788 |
| Full Name | delta like non-canonical Notch ligand 1 |
| Alias | DLK, DLK-1, Delta1, FA1, PREF1 |
| Introduction | This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Pref-1 long isoform. Ala24-Pro297 with Arg248Pro and Lys295Ser substitutions. Accession # AAA75364. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (1 µg/mL); Immunofluorescence (5-15 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human Pref-1/DLK-1/FA1 in direct ELISAs and Western Blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Pref-1 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.