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Ponatinib (AP24534)
SPC-01749
CAS No. 943319-70-8
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 50 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Bcr-Abl inhibitor ; FGFR inhibitor ; PDGFR inhibitor ; VEGFR inhibitor ; Src inhibitor ; Autophagy inhibitor
| Description |
|---|
| Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 943319-70-8 |
| Description | Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy. |
| Formula | C29H27F3N6O |
| Molecular Weight | 532.56 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | N/A |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.