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POMK/GNPTAB (-) Cell Line
SPL-01550
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| POMK/GNPTAB (-) |
| Target Information | |
|---|---|
| Target Name | GNPTAB |
| Gene Abbr. | GNPTAB |
| Gene ID | 79158 |
| Full Name | N-acetylglucosamine-1-phosphate transferase subunits alpha and beta |
| Alias | GNPTA, ICD |
| Species | Human |
| Introduction | This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010]. |
| Product Details | |
|---|---|
| Cell Line Model | HAP1 |
| Genotype | POMK/GNPTAB (-) |
| Description | POMK/GNPTAB (-) |
| Parental Cell Line | C631 |
| Handling Specifications | |
|---|---|
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.