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Zinc finger protein JACKDAW (JKD), Recombinant Protein
Cat: RP00541
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Zinc finger protein JACKDAW (JKD) , partial
Product Gene Name
JKD recombinant protein
Product Synonym Gene Name
JKD
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
55,201 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Zinc finger protein
NCBI/Uniprot Data
NCBI Accession #
NP_195935.2
NCBI GI #
30679912
NCBI GenBank Nucleotide #
NM_120393.6
NCBI GeneID
831919
NCBI Official Full Name
C2H2-like zinc finger protein
NCBI Official Symbol
JKD
NCBI Official Synonym Symbols
F15A17.180; F15A17_180; JACKDAW
NCBI Protein Information
C2H2-like zinc finger protein
NCBI Summary
JKD is a nuclear-localized putative transcription factor with three zinc finger domains. jkd mutants show a number of root patterning defects including ectopic periclinal divisions in the cortex, increased cell numbers in the cortical and epidermal layers, a disrupted QC marker expression pattern, and disorganized QC and columella cells. jkd mutants also have a reduced number of meristematic cells in their roots. JKD can interact with the SCR and SHR proteins implicated in root patterning, as well as another zinc finger transcription factor, MAGPIE. All of these interactions require the first zinc finger in JKD according to a Y2H assay. There are also transcriptional interactions among these proteins. The initiation of JKD transcription does not appear to depend on SCR and SHR, but later expression in the post-embryonic QC cells and ground tissue initials is reduced in scr and shr mutants. JKD also appears to be required for SCR transcription beginning in the embryo. There is also some evidence that JKD plays a role in promoting the movement of SHR into the nucleus, particularly in QC cells, but this may be indirect.
UniProt Gene Name
JKD
UniProt Protein Name
Zinc finger protein JACKDAW
UniProt Synonym Protein Names
ID1-like zinc finger protein 3
UniProt Primary Accession #
Q700D2
UniProt Secondary Accession #
Q0WQ14; Q9FYN0; Q9LYX0
UniProt Related Accession #
Q700D2
UniProt Comments
Transcription factor that regulates tissue boundaries and asymmetric cell division by a rapid up-regulation of 'SCARECROW' (SCR), thus controlling the nuclear localization of 'SHORT-ROOT' (SHR) and restricting its action(PubMed:17785527). Required for radial patterning and stem cell maintenance(PubMed:17785527). Counteracted by 'MAGPIE' (MGP)(PubMed:17785527). Binds to the SCR and MGP promoter sequences (PubMed:21935722). Controls position-dependent signals that regulate epidermal-cell-type patterning (PubMed:20356954).
For research use only, not for clinical use.