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Uric acid degradation bifunctional protein TTL (TTL), Recombinant Protein
Cat: RP00111
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Uric acid degradation bifunctional protein TTL (TTL)
Product Gene Name
TTL recombinant protein
Product Synonym Gene Name
TTL
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MAMEIGEDEW KVCCGSSEFA KQMSTSGPLT SQEAIYTARD IWFNQVNVTD WLEAFSAHPQ IGNTPSPSIN SDFARRSVSE QSTAFATTSA SALQELAEWN VLYKKKFGFI FIICASGRTH AEMLHALKER YENRPIVELE IAAMEQMKIT ELRMAKLFSD KAKVISETDS SSSPVSTKPQ DRLRIIGGHL NVAAEAKAPK RSRPPITTHV LDVSRGAPAA GVEVHLEVWS GTTGPSFVHG GGGVWSSVGT SATDRDGRSG PLMDLVDALN PGTYRISFDT AKYSPGCFFP YVSIVFQVTE SQKWEHFHVP LLLAPFSFST YRGS
Sequence Positions
1-324, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
31,511 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Uric acid degradation bifunctional protein
NCBI/Uniprot Data
NCBI Accession #
NP_001032093.1
NCBI GI #
79331271
NCBI GenBank Nucleotide #
NM_001037016.2
NCBI GeneID
835934
NCBI Official Full Name
transthyretin-like protein
NCBI Official Symbol
TTL
NCBI Official Synonym Symbols
allantoin synthase; ALNS; MCK7.9; MCK7_9; transthyretin-like protein
NCBI Protein Information
transthyretin-like protein
NCBI Summary
Encodes a transthyretin-like S-allantoin synthase protein that catalyzes two steps in the allantoin biosynthesis pathway by acting as a hydroxyisourate hydrolase and a 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) decarboxylase. Two alternatively spliced versions of the transcript give rise to a longer peroxisomally-targeted protein (AT5G58220.1 (called TTL1-)) and a slightly shorter cytoplasmic protein (AT5G58220.3 (called TTL2-)). Both have roughly equivalent enzymatic activity in vitro, but, allantoin biosynthesis is believed to occur in the peroxisome suggesting that the cytosolic form may participate in a different process.
UniProt Gene Name
TTL
UniProt Synonym Gene Names
OHCU decarboxylase; HIU hydrolase; HIUHase
UniProt Protein Name
Uric acid degradation bifunctional protein TTL
UniProt Synonym Protein Names
Transthyretin-like proteinIncluding the following 2 domains:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC:4.1.1.97); OHCU decarboxylase5-hydroxyisourate hydrolase (EC:3.5.2.17); HIU hydrolase; HIUHase
UniProt Primary Accession #
Q9LVM5
UniProt Secondary Accession #
Q2V2X6; Q2V2X7
UniProt Related Accession #
Q9LVM5
UniProt Comments
Involved in the last two steps of the degradation of uric acid, i.e. the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) and its stereoselective decarboxylation to (S)-allantoin. Might function as a negative regulator to modulate brassinosteroid-mediated plant growth.
For research use only, not for clinical use.