NCBI Accession #
XP_015631211.1
NCBI GenBank Nucleotide #
XM_015775725.1
NCBI Official Full Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
NCBI Official Symbol
LOC4334285
NCBI Official Synonym Symbols
TYW1
NCBI Protein Information
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Protein Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Synonym Protein Names
tRNA wybutosine-synthesizing protein 1 homolog
UniProt Primary Accession #
Q8H8N3
UniProt Secondary Accession #
Q0DN45
UniProt Related Accession #
Q8H8N3
UniProt Comments
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis .