NCBI Accession #
XP_002284299.1
NCBI GenBank Nucleotide #
XM_002284263.3
NCBI Official Full Name
tRNA (guanine(37)-N1)-methyltransferase 1
NCBI Official Symbol
LOC100241770
NCBI Protein Information
tRNA (guanine(37)-N1)-methyltransferase 1
UniProt Gene Name
VIT_19s0014g03930
UniProt Protein Name
tRNA (guanine(37)-N1)-methyltransferase 1
UniProt Synonym Protein Names
M1G-methyltransferase 1
UniProt Primary Accession #
F6H2F8
UniProt Related Accession #
F6H2F8
UniProt Comments
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.