Transcriptional activator DEMETER (DME), Recombinant Protein
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Transcriptional activator DEMETER (DME), Recombinant Protein

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Cat: RP00606
Size: 0.02 mg/ 0.1 mg/ 1 mg/ 5x1 mg
Species: Arabidopsis halleri
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Transcriptional activator DEMETER (DME), partial
Product Synonym Names
DNA glycosylase-related protein DME
Product Gene Name
DME recombinant protein
Purity
Greater than 90% as determined by SDS-PAGE.
Sequence Positions
Partial, 1-320aa
Format
Tris-based buffer, 50% glycerol
Host
E Coli
Molecular Weight
51.34 kDa
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Protein Family
Transcriptional activator

NCBI/Uniprot Data

NCBI Accession #
NP_001078527.1
NCBI GI #
145334291
NCBI GenBank Nucleotide #
NM_001085058.2
NCBI GeneID
830335
NCBI Official Full Name
HhH-GPD base excision DNA repair family protein
NCBI Official Symbol
DME
NCBI Official Synonym Symbols
AT5G04570; AT5G04580; DEMETER; T32M21.160; T32M21_160
NCBI Protein Information
HhH-GPD base excision DNA repair family protein
NCBI Summary
Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele.
UniProt Gene Name
DME
UniProt Protein Name
Transcriptional activator DEMETER
UniProt Synonym Protein Names
DNA glycosylase-related protein DME
UniProt Primary Accession #
Q8LK56
UniProt Secondary Accession #
Q1WEY5; Q84TL4; Q9LZ67; Q9LZ68; Q9LZ69
UniProt Related Accession #
Q8LK56
UniProt Comments
Transcriptional activator involved in gene imprinting. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism. Allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter. Probably acts by nicking the MEA promoter. Required for stable reproducible patterns of floral and vegetative development.

For research use only, not for clinical use.