NCBI Accession #
NP_001030889.1
NCBI GenBank Nucleotide #
NM_001035812.2
NCBI Official Full Name
phytochrome interacting factor 3-like 6
NCBI Official Symbol
PIL6
NCBI Official Synonym Symbols
phytochrome interacting factor 3-like 6; PHYTOCHROME-INTERACTING FACTOR 5; PIF5
NCBI Protein Information
phytochrome interacting factor 3-like 6
NCBI Summary
Encodes a novel Myc-related bHLH transcription factor, which physically associated with APRR1/TOC1 and is a member of PIF3 transcription factor family. Involved in shade avoidance. Functions as negative regulator of PhyB. Protein levels are modulated by phytochrome B.
UniProt Synonym Gene Names
BHLH65; EN103; PIL6; AtbHLH65; bHLH 65
UniProt Protein Name
Transcription factor PIF5
UniProt Synonym Protein Names
Basic helix-loop-helix protein 65; AtbHLH65; bHLH 65; Phytochrome interacting factor-like 6; Phytochrome-interacting factor 5; Transcription factor EN 103; bHLH transcription factor bHLH065
UniProt Primary Accession #
Q84LH8
UniProt Secondary Accession #
Q8RXG4; Q8S3D7; Q9LYT0
UniProt Related Accession #
Q84LH8
UniProt Comments
Transcription factor acting negatively in the phytochrome B signaling pathway to promote the shade-avoidance response. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin-proteasome pathway. Promotes ethylene activity in the dark. May regulate the expression of a subset of genes by binding to the G-box motif. Might be involved in the integration of light-signals to control both circadian and photomorphogenic processes. Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e.g. hypocotyl elongation in low blue light) (PubMed:26724867).