NCBI Accession #
NP_001030774.1
NCBI GenBank Nucleotide #
NM_001035697.2
NCBI Official Full Name
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Official Symbol
ICE1
NCBI Official Synonym Symbols
A. THALIANA INDUCER OF CBP EXPRESSION 1; ATICE1; INDUCER OF CBF EXPRESSION 1; SCREAM; SCRM
NCBI Protein Information
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Summary
Encodes a MYC-like bHLH transcriptional activator that binds specifically to the MYC recognition sequences in the CBF3 promoter. Mutants are defective in cold-regulated gene expression. Cold stress triggers protein degradation of nuclear GFPICE1 protein, and the RING finger protein HOS1 is required. Sumoylation of ICE1 controls CBF3/DREB1A expression and freezing tolerance.
UniProt Synonym Gene Names
BHLH116; EN45; ICE1; AtbHLH116; bHLH 116
UniProt Protein Name
Transcription factor ICE1
UniProt Synonym Protein Names
Basic helix-loop-helix protein 116; AtbHLH116; bHLH 116; Inducer of CBF expression 1; Transcription factor EN 45; Transcription factor SCREAM; bHLH transcription factor bHLH116
UniProt Primary Accession #
Q9LSE2
UniProt Secondary Accession #
Q0WR77; Q2V3S3; Q5PNR8
UniProt Related Accession #
Q9LSE2
UniProt Comments
Transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.