NCBI Accession #
NP_175222.1
NCBI GenBank Nucleotide #
NM_103684.3
NCBI Official Full Name
winged-helix DNA-binding transcription factor family protein
NCBI Official Symbol
ATE2F2
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA HOMOLOG OF E2F C; ATE2FC; E2FC; E2FC TRANSCRIPTION FACTOR; T2E6.2; T2E6_2; TRANSCRIPTION FACTOR-2 E2F2
NCBI Protein Information
winged-helix DNA-binding transcription factor family protein
NCBI Summary
Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. AtE2Fc is regulated by a balance between gene expression and ubiquitin-proteasome proteolysis. AtE2Fc might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis. E2Fc has been shown to interact with DPB in its nonphosphorylated form; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost.
UniProt Synonym Gene Names
E2F2; AtE2F2
UniProt Protein Name
Transcription factor E2FC
UniProt Synonym Protein Names
E2F transcription factor-2; AtE2F2
UniProt Primary Accession #
Q9FV70
UniProt Secondary Accession #
Q94LY0; Q9FZG7
UniProt Related Accession #
Q9FV70
UniProt Comments
Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.