NCBI Accession #
NP_565831.3
NCBI GenBank Nucleotide #
NM_129160.4
NCBI Official Full Name
E2F transcription factor 3
NCBI Official Symbol
E2F3
NCBI Official Synonym Symbols
ATE2FA; E2F transcription factor 3; E2F TRANSCRIPTION FACTOR-3 E2F3; F11F19.8; F11F19_8
NCBI Protein Information
E2F transcription factor 3
NCBI Summary
Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway.
UniProt Synonym Gene Names
E2F3; E2F4; AtE2F3
UniProt Protein Name
Transcription factor E2FA
UniProt Synonym Protein Names
E2F transcription factor-3; AtE2F3
UniProt Primary Accession #
Q9FNY0
UniProt Secondary Accession #
Q9C5B5; Q9FV69; Q9M454; Q9SJ49
UniProt Related Accession #
Q9FNY0
UniProt Comments
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation.