NCBI Accession #
NP_001078175.1
NCBI GenBank Nucleotide #
NM_001084706.1
NCBI Official Full Name
tetraticopeptide domain-containing thioredoxin
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA HSP70-INTERACTING PROTEIN 2; AT3G17870; ATHIP2; ATTDX; HIP; HSC-70 INTERACTING PROTEIN; tetraticopeptide domain-containing thioredoxin
NCBI Protein Information
tetraticopeptide domain-containing thioredoxin
NCBI Summary
Encodes a thioredoxin-like disulfide reductase. The protein interacts with the yeast Hsp70 protein Ssb2 in vitro. This interaction is sensitive to the redox status of the thioredoxin domain of AtTDX.
UniProt Synonym Gene Names
AtHIP2; AtTDX
UniProt Protein Name
TPR repeat-containing thioredoxin TDX
UniProt Synonym Protein Names
HSP70-interacting protein 2; AtHIP2; Tetratricoredoxin; AtTDX
UniProt Primary Accession #
Q8VWG7
UniProt Secondary Accession #
Q7XJ63; Q8LG82; Q9LVI2; Q9LVI3
UniProt Related Accession #
Q8VWG7
UniProt Comments
Thiol-disulfide oxidoreductase that possesses insulin disulfide bonds reducing activity, disulfide reductase, foldase chaperone and holdase chaperone activities. Heat shock causes oligomerization and formation of high molecular weiht (HMW) complexes with concomitant functional switching from a disulfide reductase and foldase chaperone to a holdase chaperone. May interact with HSP70 proteins through the TPR repeats.