TOR | Target of rapamycin

Inquiry

Cat: PA00689

Size: 50 µg

Host: Rabbit

Clonality: Polyclonal

Confirmed reactivity: Arabidopsis thaliana, Zea mays

Datasheet:

Product Info

Immunogen

KLH-conjugated synthetic peptide derived from Arabidopsis thaliana TOR protein sequence, UniProt: Q9FR53, TAIR: AT1G50030

Host

Rabbit

Clonality

Polyclonal

Purity

Immunogen affinity purified serum in PBS pH 7.4.

Format

Lyophilized

Reconstitution

For reconstitution add 50 µl of sterile water

Storage

Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Application

Western blot (WB)

Recommended dilution

1 : 5000 (WB)

Expected | apparent MW

279 kDa

Reactivity

Confirmed reactivity

Arabidopsis thaliana, Zea mays

Predicted reactivity

Cucumis sativus, Glycne max, Nicotiana tabacum, Oryza sativa, Phaseolus vulgaris, Physcomitrium patens, Populus trichocarpa, Setaria italica, Setaria viridis, Solanum tuberosum, Sorghum bicolor, Vitis vinifera

Not reactive in

Chlamydomonas reinhardtii

Additional information

TOR is a subjected to post-translational modifications (ubiquitination and phosphorylation), which can change the migration pattern in SDS gel

Description

TOR (rapamycin Target of rapamycin) is an important cell growth regulator that controls development from early embryo to seed production based on nutrient availability under environmental stress conditions. It belongs to the phosphatidylinositol 3-kinase family and is the target of the anti-proliferative drug rapamycin. AtTOR is expressed in embryo, endosperm and meristem. It acts by phosphorylation of downstream effectors recruited by partner RAPTOR. Inhibition of mRNA degradation and autophagy works by activating transcription, protein synthesis and ribosome biogenesis.

For research use only, not for clinical use.